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Classics in Chemical Neuroscience: Memantine

Shahrina Alam1, Kaelyn Skye Lingenfelter1, Aaron M Bender1

  • 1Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine , Nashville, Tennessee 37232, United States.

ACS Chemical Neuroscience
|July 25, 2017
PubMed
Summary

Memantine, a novel NMDA receptor antagonist, offers significant benefits for moderate to severe Alzheimer's disease (AD). This medication improves cognition, daily function, and delays institutionalization in AD patients.

Keywords:
3,5-dimethyladamantan-1-amine hydrochlorideAlzheimer’s diseaseMemantineN-methyl-d-aspartate (NMDA) receptorglutamatergic dysfunctionuncompetitive antagonist

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