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Structure and Computation in Immunoreagent Design: From Diagnostics to Vaccines.
Louise Gourlay1, Claudio Peri2, Martino Bolognesi3
1Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, 20133, Milan, Italy.
Trends in Biotechnology
|July 26, 2017
Summary
Structural vaccinology (SV) advances antigen design for novel diagnostics and vaccines against emerging infections, AIDS, and cancer. This approach enables engineering biomolecules with enhanced immunological properties for improved treatments.
Area of Science:
- Immunology
- Structural Biology
- Vaccine Development
Background:
- Emerging infectious diseases necessitate novel immunological diagnostic and treatment tools.
- Reverse vaccinology and structural vaccinology (SV) are advancing antigen identification and design.
- SV is poised to lead future vaccine and diagnostic development for diseases like AIDS and cancer.
Purpose of the Study:
- To review state-of-the-art methods for structure-based epitope identification and antigen design.
- To highlight the application of these methods in engineering biomolecules with improved immunological properties.
- To discuss the future perspectives of structure-based rational design for advanced immunoreagents.
Main Methods:
- Review of current literature on structure-based epitope identification.
- Analysis of antigen redesign methodologies.
- Examination of structure-based rational design principles.
Main Results:
- Structural vaccinology offers powerful approaches for antigen identification and design.
- These methods facilitate the engineering of biomolecules for enhanced diagnostic and therapeutic applications.
- Structure-based design holds significant promise for developing advanced immunoreagents.
Conclusions:
- Structural vaccinology is a key technology for developing next-generation vaccines and diagnostics.
- Rational design based on structural information can yield improved immunological tools.
- Further development in SV will impact the fight against challenging diseases.
Keywords:
antigen engineeringepitope-driven vaccine designimmunoreagentsin silico epitope discoverystructural vaccinologyMore Related Videos
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