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Related Experiment Video

Updated: Feb 26, 2026

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[DIAN/DIAN-J/DIAN-TU].

Hiroyuki Shimada1, Mikio Shoji, Takeshi Ikeuchi

  • 1Osaka City University Graduate School of Medicine, Clinical Research Center for Dementia.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|July 26, 2017
PubMed
Summary
This summary is machine-generated.

Biomarker changes in autosomal dominant Alzheimer's disease begin 20-25 years before symptoms. The Dominantly Inherited Alzheimer's Network (DIAN) study tracks these early Alzheimer's disease changes.

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Area of Science:

  • Neuroscience
  • Genetics
  • Biomarkers

Background:

  • Autosomal dominant Alzheimer's disease (ADAD) is a rare genetic form of AD.
  • The Dominantly Inherited Alzheimer's Network (DIAN) study investigates ADAD.
  • Early detection of pathophysiological changes is crucial for intervention.

Purpose of the Study:

  • To compare pathophysiological markers in mutation carriers versus non-carriers in ADAD.
  • To establish the timeline of biomarker changes preceding symptom onset in ADAD.
  • To implement and harmonize global ADAD research efforts, including DIAN-Japan (DIAN-J).

Main Methods:

  • Observational study comparing biomarker profiles.
  • Utilizing data from the DIAN observational study and its global extensions.
  • Implementing compatible research protocols across international sites like DIAN-J.

Main Results:

  • Biomarker changes in the brain initiate 20-25 years prior to clinical symptom onset in ADAD mutation carriers.
  • DIAN-J successfully implemented the DIAN study protocols, ensuring global research compatibility.
  • The API study corroborated DIAN findings regarding early biomarker alterations in familial AD.

Conclusions:

  • Early-onset pathophysiological changes are detectable decades before symptoms in autosomal dominant Alzheimer's disease.
  • Global harmonization of research, exemplified by DIAN-J, is vital for advancing ADAD studies.
  • Ongoing clinical trials (DIAN-TU, API study) are testing interventions targeting these early changes.