Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk
Andrea Morandi1, Elisa Giannoni1, Paola Chiarugi2
1Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale G.B. Morgagni, 50, 50134 Florence, Italy.
Trends in Cancer
|July 26, 2017
Summary
The tumor microenvironment influences cancer malignancy and metastasis. Targeting metabolic reprogramming and tumor-stroma interactions offers new therapeutic strategies for aggressive cancers.
Area of Science:
- Oncology
- Cancer Biology
- Metabolism
Background:
- The tumor microenvironment (TME) critically influences tumor progression, malignancy, and metastasis.
- Aggressive cancer cells exhibit metabolic plasticity, stemness, and chemoresistance.
- Stromal cells like cancer-associated fibroblasts, endothelial cells, and immune cells shape cancer cell metabolism.
Purpose of the Study:
- To review current knowledge on metabolic reprogramming in cancer.
- To discuss the metabolic crosstalk between tumor and stroma.
- To explore therapeutic compounds targeting tumor-stroma metabolic symbiosis.
Main Methods:
- Literature review of recent studies on cancer metabolism.
- Analysis of the role of the TME in cancer progression.
- Identification of therapeutic strategies targeting metabolic pathways.
Main Results:
- Metabolic reprogramming is a hallmark of aggressive cancers.
- Tumor-stroma metabolic crosstalk significantly impacts cancer behavior.
- Targeting metabolic symbiosis presents a promising therapeutic avenue.
Conclusions:
- Understanding cancer cell metabolism and its interaction with the TME is crucial for developing effective cancer therapies.
- Targeting metabolic vulnerabilities in the tumor-stroma axis holds potential for overcoming chemoresistance and metastasis.
Keywords:
Warburg metabolismmetabolic reprogrammingoxidative phosphorylationtumor microenvironmenttumor–stroma crosstalkMore Related Videos
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