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Amphiregulin in Cancer: New Insights for Translational Medicine

Qixia Xu1, Paul Chiao2, Yu Sun3

  • 1Key Lab of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine, Shanghai 200031, China; Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiaotong University School of Medicine, Shanghai 200240, China.

Trends in Cancer
|July 26, 2017
PubMed

Insights

Amphiregulin (AREG) plays a key role beyond cancer cells, impacting the tumor microenvironment (TME) and driving therapeutic resistance. Understanding AREG

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • Extensive research exists on amphiregulin (AREG) in human cancers, primarily focusing on its cell-autonomous roles in epithelial malignancies.
  • Emerging evidence indicates AREG's presence and function within the tumor microenvironment (TME).

Purpose of the Study:

  • To review and discuss novel concepts of AREG's role in tumor biology.
  • To highlight the implications of AREG's TME functions for translational cancer medicine.

Main Methods:

  • Literature review and synthesis of recent studies on AREG.
  • Discussion of emerging concepts in AREG tumor biology.

Main Results:

  • AREG is present in the TME and contributes to therapeutic resistance.
  • AREG exhibits functions beyond cell-autonomous effects in epithelial cancers.

Conclusions:

  • AREG's role in the TME is critical for understanding cancer progression and therapeutic outcomes.
  • Targeting AREG within the TME may offer new avenues for cancer treatment.
Keywords:
amphiregulinimmunosuppressionsecretory phenotypetherapeutic resistancetranslational medicinetumor microenvironment

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