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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Aspergillus calidoustus case series and review of the literature
Justin Seroy1, Philip Antiporta1, Shellee A Grim1,2
1Division of Infectious Diseases, Department of Internal Medicine, Loyola University Medical Center, Maywood, IL, USA.
Abstract:
Aspergillus calidoustus, previously classified as Aspergillus ustus, is an emerging pathogen in immunocompromised persons. We describe four recent cases of A. calidoustus and review 37 additional cases of A. calidoustus (n = 8) or A. ustus (n = 29) published through June 2016. Twenty (49%) cases occurred in patients with hematologic malignancy and/or receipt of hematopoietic cell transplantation, and 13 (32%) occurred in solid organ transplant recipients. Antifungal susceptibility was reported in 49% of cases and in 42% treatment failed. Overall mortality was 66% and, where reported, attributable mortality was 30%. A. calidoustus infection is associated with a high mortality rate and frequently displays in vitro antifungal resistance.
Insights
Aspergillus calidoustus, an emerging fungal pathogen, poses a significant threat to immunocompromised individuals. Infections are linked to high mortality and frequent antifungal resistance, demanding urgent clinical attention.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Aspergillus calidoustus, formerly Aspergillus ustus, is an emerging opportunistic pathogen.
- It primarily affects immunocompromised individuals, including those with hematologic malignancy or solid organ transplants.
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