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Triggerable tough hydrogels for gastric resident dosage forms.

Jinyao Liu1, Yan Pang1, Shiyi Zhang1

  • 1Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

Nature Communications
|July 27, 2017
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Summary

Researchers developed novel triggerable tough hydrogels for prolonged drug delivery in the stomach. These strong, adaptable hydrogels offer a new solution for gastric resident drug depots, overcoming limitations of current materials.

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Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Drug Delivery Systems

Background:

  • Gastric resident systems are crucial for diagnosing and treating patients, but existing materials like thermoplastics and thermosets have limitations.
  • Current gastric drug delivery systems often face drawbacks related to prolonged use and mechanical stability within the gastrointestinal tract.

Purpose of the Study:

  • To develop and evaluate novel triggerable tough hydrogels for prolonged gastric residence and drug delivery.
  • To create a hydrogel system that is ingestible, adaptable, mechanically robust, triggerable, and capable of sustained drug release.

Main Methods:

  • Development of triggerable tough hydrogels with specific mechanical and swelling properties.
  • Evaluation of hydrogel performance in a large animal model for gastric residence and drug release.
  • Assessment of the hydrogels' ability to withstand gastrointestinal motility forces and be triggered for dissolution.

Main Results:

  • The novel triggerable tough hydrogels demonstrated the required mechanical integrity and adaptability for prolonged gastric residence.
  • The hydrogels successfully loaded and released drugs over an extended period.
  • The system proved to be triggerable, allowing for controlled dissolution on demand.

Conclusions:

  • Triggerable tough hydrogels represent a promising new class of materials for prolonged gastric resident drug depots.
  • These hydrogels overcome limitations of traditional materials and offer potential applications in bariatric interventions, drug delivery, and tissue engineering.