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[Prevention and correction of cognitive dysfunction after general anesthesia].

A Yu Novikov1, V A Kovalev1, N V Vinichuk2

  • 1Primorye regional clinical hospital #1, Vladivostok, Russia.

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|July 27, 2017
PubMed
Summary

Intraoperative cytoflavin improved cognitive function recovery in surgical patients. This intervention facilitated faster adaptation and return to baseline cognitive status post-anesthesia.

Keywords:
cytoflavindesfluranepost-operative cognitive dysfucntiontracheal extubation

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Area of Science:

  • Anesthesiology
  • Neuroscience
  • Pharmacology

Background:

  • Cognitive dysfunction is a potential complication following surgery and anesthesia.
  • Early detection and management of cognitive changes are crucial for patient recovery.
  • Thyroidectomy is a common surgical procedure that can impact cognitive function.

Purpose of the Study:

  • To assess the efficacy of intraoperative cytoflavin in preventing and correcting cognitive dysfunction.
  • To evaluate the impact of cytoflavin on post-anesthesia recovery and cognitive status in surgical patients.
  • To investigate the role of cytoflavin in patients undergoing thyroidectomy without prior neurological or psychosomatic disorders.

Main Methods:

  • A randomized controlled trial involving 60 female patients undergoing thyroidectomy.
  • Patients received either cytoflavin infusion or a placebo (5% glucose solution) during surgery.
  • Cognitive function was assessed preoperatively and at 6, 24, and 48 hours postoperatively.
  • Anesthesia was induced using desflurane, with waking time and tracheal extubation time recorded.

Main Results:

  • Patients receiving intraoperative cytoflavin demonstrated earlier post-anesthesia adaptation.
  • The cytoflavin group exhibited a more rapid recovery of initial cognitive status compared to the control group.
  • No significant differences were noted in waking time or tracheal extubation time between groups.

Conclusions:

  • Intraoperative administration of cytoflavin is effective in enhancing cognitive recovery after surgery.
  • Cytoflavin aids in mitigating post-anesthetic cognitive impairment in surgical patients.
  • The findings support the use of cytoflavin for optimizing cognitive outcomes in the perioperative period.