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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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[TREATMENT OF SEVERE INTRAPATUM ASPHYXIA.]

A A Zarubin, I E Golub, O S Fedorova

    Anesteziologiia I Reanimatologiia
    |February 23, 2018
    PubMed
    Summary

    Systemic therapeutic hypothermia effectively treated newborns with severe birth asphyxia, showing no deaths. Early convulsions predicted outcomes, while conditions like meconium aspiration syndrome complicated recovery.

    Area of Science:

    • Neonatalogy
    • Perinatal Medicine
    • Pediatric Critical Care

    Background:

    • Severe birth asphyxia poses significant risks to newborns.
    • Hypoxic-ischemic encephalopathy (HIE) is a major complication.
    • Therapeutic hypothermia is a recognized treatment modality.

    Purpose of the Study:

    • To evaluate the efficacy of systemic therapeutic hypothermia in treating newborns with severe birth asphyxia.
    • To identify predictors of clinical outcomes in neonates with HIE.

    Main Methods:

    • Retrospective, open-controlled clinical research.
    • Involved 33 neonates treated with therapeutic hypothermia using the "Allon 2001" apparatus.
    • Data collected on neurological status, Apgar scores, and clinical course.

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    Main Results:

    • 60.6% of neonates presented with Sarnat II and 39.4% with Sarnat III HIE.
    • Convulsions within the first hour of life were observed in 57.6% of newborns.
    • No deaths occurred in the study group, indicating treatment effectiveness.

    Conclusions:

    • Early convulsions (within the first hour) are reliable predictors of HIE severity.
    • Apgar scores correlate with acid-base balance and HIE severity.
    • Meconium aspiration syndrome and amniotic infection complicate HIE and necessitate prolonged ventilation and cardiotonics.