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Updated: Feb 25, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure
Fernando Mendes Paschoal1,2, Ricardo de Carvalho Nogueira1, Marcelo de Lima Oliveira1
1Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Cirurgia Neurológica, Laboratório de Neurosonologia e Hemodinâmica Cerebral, São Paulo SP, Brasil.
Abstract:
Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.
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