Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

935
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
935

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuromodulation and Exercise Therapy: A Synergistic Approach to Improve Physical Mobility.

Archives of medical research·2025
Same author

Near-infrared spectroscopy of the cerebellum in motor activation tasks.

Scientific reports·2025
Same author

Predictive Analysis of Amyotrophic Lateral Sclerosis Progression and Mortality in a Clinic Cohort From Singapore.

Muscle & nerve·2025
Same author

Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection.

Frontiers in immunology·2025
Same author

Repetitive Transcranial Magnetic Stimulation for Motor Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials With Low Risk of Bias.

Neuromodulation : journal of the International Neuromodulation Society·2024
Same author

Anti-IgLON5 Disease Presenting with Esophageal Achalasia and Hypercapnic Respiratory Failure.

The American journal of medicine·2024
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.5K

Immunotherapy for diabetic amyotrophy.

Yee Cheun Chan1, Yew Long Lo, Edwin Sy Chan

  • 1Division of Neurology, National University Hospital, 1E, Kent Ridge Road, NUHS Tower Block, Level 10, Singapore, Singapore, 119228.

The Cochrane Database of Systematic Reviews
|July 27, 2017
PubMed
Summary
This summary is machine-generated.

This review found no randomized trials proving immunotherapy benefits for diabetic amyotrophy, a nerve condition in diabetes mellitus patients. More research is needed to establish effective treatments for this painful condition.

More Related Videos

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.3K
Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
12:12

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes

Published on: June 16, 2011

14.0K

Related Experiment Videos

Last Updated: Feb 25, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.5K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.3K
Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
12:12

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes

Published on: June 16, 2011

14.0K

Area of Science:

  • Neurology
  • Endocrinology
  • Immunology

Background:

  • Diabetic amyotrophy, also known as diabetic lumbosacral radiculoplexus neuropathies, presents with progressive, asymmetrical pain and weakness in the lower limbs of people with diabetes mellitus.
  • This condition may stem from immune-mediated inflammatory microvasculitis causing nerve ischemia, suggesting immunotherapy could be beneficial.

Purpose of the Study:

  • To systematically review randomized controlled trials assessing the efficacy of immunotherapy for treating diabetic amyotrophy.

Main Methods:

  • Searched major databases (Cochrane Neuromuscular, CENTRAL, MEDLINE, Embase) up to September 2016.
  • Included randomized and quasi-randomized trials of any immunotherapy for diabetic amyotrophy meeting specific diagnostic criteria.
  • Two authors independently screened references and selected eligible studies.

Main Results:

  • Only one completed placebo-controlled trial using intravenous methylprednisolone was identified, but its results were unpublished and unavailable for analysis.
  • The identified trial had unclear risk of bias and a high risk of selective reporting; adverse events were not reported.
  • Updated searches in September 2016 yielded no new relevant trials.

Conclusions:

  • Currently, there is a lack of evidence from randomized trials to support or refute the use of any immunotherapy for diabetic amyotrophy.
  • Further high-quality randomized controlled trials are necessary to determine the effectiveness of immunotherapies in managing this condition.