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Sublingual misoprostol and hyperpyrexia: case report with temperature curve
Paul Nkemtendong Tolefac1,2, Jacqueline Ze Minkande3
1Douala General Hospital, Douala, Cameroon. ptolefac15@gmail.com.
BMC Research Notes
|July 28, 2017
Summary
Misoprostol effectively treats postpartum hemorrhage (PPH). However, be aware of potential side effects like fever and shivering, which can be managed with standard treatments.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Misoprostol is recommended by major health organizations (WHO, FIGO, ACOG) for postpartum hemorrhage (PPH) due to its safety and cost-effectiveness.
- Potential adverse effects of misoprostol include hyperpyrexia (fever) and shivering.
Observation:
- A case study involving a 30-year-old Cameroonian woman with primary PPH after vaginal delivery at 40 weeks gestation.
- Sublingual misoprostol was administered for PPH management.
- The treatment successfully resolved PPH but induced shivering and hyperpyrexia.
Findings:
- Sublingual misoprostol administration for PPH can lead to hyperpyrexia and shivering.
- These adverse effects were successfully managed with paracetamol and cooling measures.
- This highlights a specific adverse event profile associated with misoprostol in PPH treatment.
Implications:
- Clinicians should anticipate and monitor for fever and shivering when using misoprostol for PPH.
- Prompt management strategies involving antipyretics and cooling are effective.
- Awareness of these side effects is crucial for safe and effective PPH management.
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