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Fungal Phylum Microsporidia01:28

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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Fusarium Keratitis in Germany.

Grit Walther1, Serena Stasch2, Kerstin Kaerger2

  • 1National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany Grit.Walther@hki-jena.de.

Journal of Clinical Microbiology
|July 28, 2017
PubMed
Summary

Fusarium keratitis, a severe eye infection, is increasingly seen in Germany, particularly linked to contact lens use. This fungal infection often leads to poor outcomes, necessitating advanced treatments.

Keywords:
Fusariumantifungal susceptibility testingcontact lensfungal keratitis

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Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Fusarium keratitis is a destructive fungal eye infection, historically common in tropical regions.
  • An increasing incidence of Fusarium keratitis is now reported in temperate climates, including Germany.
  • The German National Reference Center observed a rise in Fusarium cases since 2014.

Purpose of the Study:

  • To present the first German case series of Fusarium keratitis.
  • To identify Fusarium species involved and their clinical significance.
  • To analyze risk factors and treatment outcomes.

Main Methods:

  • Retrospective analysis of 22 Fusarium isolates from ocular samples (2014-2015).
  • Identification of Fusarium species complexes: Fusarium solani species complex (FSSC), Fusarium oxysporum species complex (FOSC), and Fusarium fujikuroi species complex (FFSC).
  • Antifungal susceptibility testing (MIC) and clinical outcome assessment.

Main Results:

  • FSSC was the predominant species in definite infections (13/15 cases).
  • Contact lens wear was identified as the primary risk factor.
  • Adverse outcomes were common, with 10 patients requiring keratoplasty or enucleation; natamycin use was limited.

Conclusions:

  • Fusarium keratitis, especially FSSC, is a significant and growing clinical issue in Germany.
  • Contact lens wear is a major risk factor for this infection.
  • Effective treatment options like natamycin are underutilized, contributing to poor outcomes.