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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Autophagy regulated by miRNAs in colorectal cancer progression and resistance

Andrew Fesler1, Hua Liu1, Ning Wu1,2

  • 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.

Cancer Translational Medicine
|July 28, 2017
PubMed

Insights

MicroRNAs (miRNAs) epigenetically regulate autophagy, a cellular recycling process. This review highlights miRNA

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Epigenetics

Background:

  • Autophagy is a crucial catabolic process for cellular macromolecule breakdown and recycling.
  • Epigenetic regulation by microRNAs (miRNAs) is increasingly recognized in human cancers.
  • Autophagy significantly influences colorectal cancer progression and chemotherapy resistance.

Purpose of the Study:

  • To review recent advancements in understanding miRNA regulation of autophagy in colorectal cancer.
  • To elucidate the role of miRNAs in mediating autophagy's functions in colorectal cancer.

Main Methods:

  • Literature review of recent studies on miRNA-autophagy interactions in colorectal cancer.
  • Analysis of molecular mechanisms linking miRNAs, autophagy, and colorectal cancer.

Main Results:

  • miRNAs are directly involved in modulating autophagy in colorectal cancer.
  • Specific miRNAs can promote or inhibit autophagy, impacting cancer progression.
  • miRNA-mediated autophagy regulation contributes to chemotherapy resistance.

Conclusions:

  • miRNA regulation of autophagy is a key epigenetic mechanism in colorectal cancer.
  • Targeting miRNA-autophagy pathways presents potential therapeutic strategies for colorectal cancer.
  • Further research is needed to fully elucidate these complex interactions.
Keywords:
Autophagycancer stem cellchemotherapycolorectal cancermicroRNA

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