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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Stemness-Related Markers in Cancer.

Wenxiu Zhao1, Yvonne Li2, Xun Zhang1

  • 1Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

Cancer Translational Medicine
|December 26, 2017
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and therapy resistance. This review focuses on stemness markers, including transcription factors, surface proteins, and pathways in human cancers.

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Area of Science:

  • Oncology
  • Stem Cell Biology

Background:

  • Cancer stem cells (CSCs) are crucial for tumor initiation, growth, and therapeutic resistance.
  • CSCs possess self-renewal and differentiation capabilities, similar to embryonic and adult stem cells.
  • A 'stemness' phenotype in CSCs is associated with specific markers not found in normal somatic cells.

Purpose of the Study:

  • To review current knowledge on stemness-related markers in human cancers.
  • To highlight key transcription factors, protein surface markers, and signaling pathways associated with CSCs.

Main Methods:

  • Literature review of current research on cancer stem cell markers.
  • Focus on identifying and summarizing key stemness-associated molecules and pathways.

Main Results:

  • CSCs exhibit unique markers contributing to their 'stemness' phenotype.
  • Identified key transcription factors, surface proteins, and signaling pathways involved in CSCs.
  • These markers are critical for understanding tumor initiation, progression, and treatment resistance.

Conclusions:

  • Stemness markers are fundamental to understanding cancer stem cell biology.
  • Targeting these markers holds potential for novel cancer therapies.
  • Further research into stemness pathways can improve treatment strategies for various human cancers.