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Updated: Feb 25, 2026
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Cardiac status in children with acute poststreptococcal glomerulonephritis
Tushar Idhate1, Syed Ahmed Zaki1, Preeti Shanbag1
1Department of Pediatrics, Division of Pediatric Nephrology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India.
Summary
Cardiac abnormalities like prolonged QTc and reduced ejection fraction can occur in children with acute poststreptococcal glomerulonephritis (PSGN). These cardiac issues are usually transient, resolving within three months, highlighting the importance of monitoring cardiac status.
Area of Science:
- Pediatric Nephrology
- Pediatric Cardiology
- Cardiovascular Complications
Background:
- Acute poststreptococcal glomerulonephritis (PSGN) is a common childhood kidney disease.
- Cardiac involvement is frequent in PSGN, yet cardiac status in affected children is understudied.
Purpose of the Study:
- To investigate the cardiac status in children diagnosed with acute poststreptococcal glomerulonephritis.
- To assess the prevalence and transient nature of cardiac abnormalities in pediatric PSGN.
Main Methods:
- Prospective study of 30 children (1 month to 12 years) with PSGN.
- Electrocardiogram (ECG) and echocardiography performed at admission and at 6 and 12 weeks.
- Analysis of QTc interval, left ventricular ejection fraction (LVEF), and other echocardiographic parameters.
Main Results:
- 11 patients (37%) had prolonged QTc interval, mostly with hypertension.
- 7 patients (23%) presented with reduced LVEF (<60%), associated with other diastolic dysfunction markers.
- Cardiac abnormalities resolved by 6-12 weeks in all patients, indicating transient myocardial dysfunction.
Conclusions:
- ECG and echocardiographic abnormalities are common in acute PSGN but typically transient.
- While hypertension is a factor, primary myocardial dysfunction should be considered in PSGN cardiac complications.
- Complete cardiac recovery is expected within three months for most children with PSGN.
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