Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sedative/hypnotic dependence: patient stabilization, tolerance testing, and withdrawal.

P J Perry, B Alexander

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    O blood usage trends in the pediatric population 2015-2019: A multi-institutional analysis.

    Transfusion·2025
    Same author

    Olfaction in the Anthropocene: NO<sub>3</sub> negatively affects floral scent and nocturnal pollination.

    Science (New York, N.Y.)·2024
    Same author

    Post-discharge oral antimicrobial use among hospitalized patients across an integrated national healthcare network.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    SU-E-T-401: Evaluation of Initial Setup Accuracy and Intra-Fraction Motion for Spine SBRT Using Stereotactic Body Frames.

    Medical physics·2017
    Same author

    Spectroscopic Performance of Thick HgI<sub>2</sub> Detectors.

    IEEE transactions on nuclear science·2017
    Same author

    Accuracy and precision of non-invasive cardiac output monitoring devices in perioperative medicine: a systematic review and meta-analysis†.

    British journal of anaesthesia·2017
    Same journal

    Profile of prescription medication in a pediatric population.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    SI units in drug therapeutics.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Physicians' review of significant interventions by clinical pharmacists in inpatient care.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Possible interaction of ranitidine with phenytoin.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Famotidine-associated mental confusion in elderly patients.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Intravenous self-administration of elemental mercury: efficacy of dimercaprol therapy.

    Drug intelligence & clinical pharmacy·1988
    See all related articles

    Physical dependence on sedative/hypnotic drugs causes withdrawal symptoms similar to alcohol but longer-lasting and less intense. Diazepam is recommended for managing withdrawal due to its rapid action and long-acting metabolite, facilitating a gradual tapering schedule.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Neuroscience

    Background:

    • Physical dependence on sedative/hypnotic medications is a significant clinical issue.
    • Withdrawal syndromes resemble alcohol withdrawal but are prolonged and less severe.
    • Shorter-acting sedative/hypnotics may pose a higher risk for withdrawal reactions.

    Purpose of the Study:

    • To outline a clinical approach for managing sedative/hypnotic drug dependence.
    • To identify optimal pharmacological agents for withdrawal management.
    • To discuss the role of diazepam in treating sedative/hypnotic dependence.

    Main Methods:

    • Initial symptom stabilization in dependent users.
    • Tolerance testing to assess physiological dependence.

    Related Experiment Videos

  • Gradual withdrawal using long-acting agents like diazepam or phenobarbital.

    • Main Results:

    • Diazepam is identified as a preferred agent for managing sedative/hypnotic dependence.
    • Diazepam's rapid absorption and distribution aid in stabilization and testing.
    • Its metabolite, desmethyldiazepam, supports a sustained, tapered withdrawal regimen.

    Conclusions:

    • Diazepam is a suitable choice for treating sedative/hypnotic drug dependence.
    • Its pharmacokinetic profile makes it effective for both initial stabilization and long-term withdrawal.
    • A structured approach involving stabilization, testing, and tapering is crucial for managing dependence.