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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Updated: Feb 25, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Immunotherapy in Multiple Myeloma.

Charise Gleason, Donna D Catamero

    Seminars in Oncology Nursing
    |July 29, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Monoclonal antibodies (mAbs) have significantly improved multiple myeloma (MM) treatment outcomes. These targeted therapies offer a well-tolerated option for patients when managed with proper pre-medications and nursing care.

    Keywords:
    daratumumabelotuzumabmonoclonal antibodiesmultiple myeloma

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    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled plasma cell proliferation.
    • Therapeutic advancements have dramatically improved clinical outcomes for MM patients.
    • Monoclonal antibodies (mAbs) represent a significant development in MM treatment.

    Purpose of the Study:

    • To review the application of monoclonal antibodies (mAbs) in the treatment of multiple myeloma (MM).
    • To discuss the management of common side effects associated with mAb therapy in MM.

    Main Methods:

    • A comprehensive review of existing journal articles focusing on mAbs in MM treatment was conducted.
    • Literature search focused on efficacy, safety, and side effect management of mAbs.

    Main Results:

    • The development and use of mAbs have been linked to improved clinical outcomes in MM.
    • mAbs demonstrate favorable toxicity profiles compared to traditional therapies.
    • Effective management of side effects is achievable with appropriate pre-medications and nursing interventions.

    Conclusions:

    • Monoclonal antibodies are a valuable and effective therapeutic option for multiple myeloma.
    • With proper supportive care, mAbs are well-tolerated by MM patients.
    • Continued research and optimized management strategies will further enhance mAb therapy in MM.