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Minimal clinically important difference of the Modified Fatigue Impact Scale in Parkinson's disease

Benzi M Kluger1, Sanjana Garimella1, Cynthia Garvan2

  • 1Department of Neurology of the University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Parkinsonism & Related Disorders
|July 29, 2017
PubMed
Abstract

Insights

The Modified Fatigue Impact Scale (MFIS) is a valid tool for measuring Parkinson's disease (PD) fatigue. Its minimal clinically important difference (MCID) has been determined, aiding in therapeutic trial interpretation.

Area of Science:

  • Neurology
  • Psychometrics
  • Clinical Trials

Background:

  • Fatigue is a prevalent and disabling symptom in Parkinson's disease (PD).
  • Currently, no evidence-based treatments exist for PD-related fatigue.
  • Established fatigue scales lack a determined minimal clinically important difference (MCID), hindering clinical trial design and interpretation.

Purpose of the Study:

  • To determine the minimal clinically important difference (MCID) for the Modified Fatigue Impact Scale (MFIS) in Parkinson's disease patients.
  • To validate the MFIS as a measure of fatigue in PD.

Main Methods:

  • Secondary data analysis of 94 PD participants from an acupuncture trial for PD fatigue.
  • Utilized standard psychometric approaches for validity assessment.
  • Employed an anchor-based approach to establish the MCID for the MFIS.

Main Results:

  • The MFIS demonstrated strong concurrent validity with other outcome measures.
  • High internal consistency was observed for the MFIS.
  • Determined MCID values: 13.8 for total MFIS, 6.8 for MFIS cognitive subscore, and 6.2 for MFIS physical subscore.

Conclusions:

  • The Modified Fatigue Impact Scale (MFIS) is a validated and multidimensional instrument for assessing fatigue in Parkinson's disease.
  • The study successfully established demonstrable MCID values for the MFIS, crucial for clinical research.
Keywords:
FatigueMinimal clinically important differenceModified Fatigue Impact ScaleParkinson's diseaseValidity

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