Related Experiment Video

Updated: Feb 25, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.6K

Relation between serum calcium levels and mortality in patients with coronary artery disease

Shao-di Yan1, Yong Peng2, Wei Liu2

  • 1Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|July 29, 2017
PubMed

Insights

Higher serum calcium levels were associated with reduced in-hospital and long-term mortality in patients with coronary artery disease (CAD). This finding suggests serum calcium is a key predictor for cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Calcium plays a vital role in numerous biological processes, particularly those implicated in cardiovascular disease (CVD).
  • Understanding the prognostic value of serum calcium in patients with established coronary artery disease (CAD) is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between baseline serum calcium levels and both short-term (in-hospital) and long-term mortality in patients diagnosed with CAD.

Main Methods:

  • A cohort of 3109 patients with confirmed CAD was analyzed.
  • Patients were stratified into quartiles based on admission serum calcium levels.
  • Multivariable Logistic and Cox regression analyses were employed to assess in-hospital and long-term mortality, respectively.

Main Results:

  • The mean serum calcium level was 2.20±0.15 mmol/L.
  • Patients in the upper quartiles of serum calcium exhibited significantly lower in-hospital mortality (HRs ranging from 0.223 to 0.391) and long-term mortality (HRs ranging from 0.476 to 0.614) compared to the lowest quartile.
  • These associations remained consistent across subgroups, including stable CAD, acute coronary syndrome (ACS), and discharged patients.

Conclusions:

  • Serum calcium is an independent predictor of both in-hospital and long-term mortality in patients with CAD.
  • Further research is needed to elucidate the underlying mechanisms and explore potential benefits of calcium supplementation in hypocalcemic patients.
Abstract

More Related Videos

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.2K
Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.7K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
578
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
755
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.3K
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
474
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
768