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Updated: Feb 25, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
Published on: July 21, 2017
Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes
Olusola Olalekan Elekofehinti1, Oluwamodupe Cecilia Ejelonu1, Jean Paul Kamdem1
1Olusola Olalekan Elekofehinti, Department of Biochemistry, Federal University of Technology, Akure 340252, Ondo State, Nigeria.
Abstract:
Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.
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