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Updated: Feb 25, 2026

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
Published on: March 22, 2018
Olfactory Cued Learning Paradigm
Gary Liu1,2, Cynthia K McClard2,3, Burak Tepe1
1Program in Developmental Biology, Baylor College of Medicine, Houston, USA.
Abstract:
Sensory stimulation leads to structural changes within the CNS (Central Nervous System), thus providing the fundamental mechanism for learning and memory. The olfactory circuit offers a unique model for studying experience-dependent plasticity, partly due to a continuous supply of integrating adult born neurons. Our lab has recently implemented an olfactory cued learning paradigm in which specific odor pairs are coupled to either a reward or punishment to study downstream circuit changes. The following protocol outlines the basic set up for our learning paradigm. Here, we describe the equipment setup, programming of software, and method of behavioral training.
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