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Updated: Feb 25, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
Published on: April 23, 2017
General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the
Xiang Fei1, Megan E Zavorka2, Guillaume Malik1
1Department of Chemistry, University of Nebraska , Lincoln, Nebraska 68588-0304, United States.
Abstract:
A generalized strategy is presented for the rapid assembly of a set of bivalent ligands with a variety of linking functionalities from a common monomer. Herein, an array of phosphatase-inert mannose-6-phosphonate-presenting ligands for the cation-independent-mannose 6-phosphate receptor (CI-MPR) is constructed. Receptor binding affinity varies with linking functionality-the simple amide and 1,5-triazole(tetrazole) being preferred over the 1,4-triazole. This approach is expected to find application across chemical biology, particularly in glycoscience, wherein multivalency often governs molecular recognition.
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