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Updated: Feb 25, 2026
09:11
Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
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Rationale for Modernising Imaging in Advanced Prostate Cancer
Anwar R Padhani1, Frederic E Lecouvet2, Nina Tunariu3
1Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex, UK.
European Urology Focus
|July 30, 2017
Summary
Accurate imaging is crucial for advanced prostate cancer (APC). Positron emission tomography (PET)/CT and whole-body MRI (WB-MRI) show higher accuracy for detecting bone metastases than standard scans, improving patient management.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Effective management of advanced prostate cancer (APC) requires precise methods for assessing metastatic disease burden.
- Current imaging techniques like bone scans and CT have limitations in detecting bone metastases.
Purpose of the Study:
- To critically review and compare imaging modalities for diagnosing and monitoring metastatic APC.
- To evaluate the availability, performance, and limitations of various imaging methods for bone and soft tissue disease.
Main Methods:
- Expert panel review of imaging modalities for advanced prostate cancer.
- Comparative analysis of positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WB-MRI), CT, and bone scans.
Main Results:
- Meta-analyses indicate PET/CT and WB-MRI are more accurate than CT and bone scans for bone lesion detection.
- Pooled sensitivity for bone disease: WB-MRI (97%), choline (CH)-PET/CT (91%), bone scans (79%).
- Pooled specificity for bone metastases: CH-PET/CT (99%), WB-MRI (95%), bone scans (82%).
Conclusions:
- Standardization of WB-MRI and PET/CT acquisition, interpretation, and reporting is necessary for clinical trials.
- WB-MRI and PET/CT show promise for improving detection and treatment response assessment in APC.
- Consensus recommendations and validation in clinical trials are needed for these advanced imaging techniques.
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