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Thyrotropin binding inhibitor immunoglobulin. Its pathogenetic importance in hypothyroidism
American Journal of Diseases of Children (1960)
|October 1, 1986
Summary
Thyrotropin binding inhibitor immunoglobulin (TBII) was detected in two patients with hypothyroidism. TBII may play a role in neonatal hypothyroidism and autoimmune thyroiditis without goiter.
Area of Science:
- Endocrinology
- Immunology
- Pediatrics
Background:
- Hypothyroidism is a condition characterized by insufficient thyroid hormone production.
- Thyrotropin binding inhibitor immunoglobulin (TBII) is an autoantibody that can interfere with thyroid function.
Observation:
- Two pediatric patients with hypothyroidism presented with detectable serum TBII levels.
- Case 1: Neonatal hypothyroidism due to maternal transfer of TBII.
- Case 2: An 8-year-old girl with Down's syndrome, myxedema, and central precocious puberty, later diagnosed with chronic lymphocytic thyroiditis and high TBII activity.
Findings:
- TBII was present in both patients with hypothyroidism.
- TBII demonstrated significant in vitro inhibition of thyroid adenyl cyclase activity.
- The findings suggest TBII's pathogenic role in specific thyroid conditions.
Implications:
- TBII may be a key factor in the development of neonatal hypothyroidism.
- TBII could be implicated in nongoitrous autoimmune thyroiditis, even without a visible goiter.
- Understanding TBII's role can aid in diagnosing and managing certain autoimmune thyroid disorders.