Related Experiment Video
Updated: Feb 25, 2026
07:39
A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals
Published on: June 25, 2018
7.8K
Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China
Xiu Ting Li1, Peng Fei Yu2, Yan Gao3
1Nanjing Prevention and Treatment Genter for Occupational Disease, Nanjing 210042, Jiangsu, China.
Biomedical and Environmental Sciences : BES
|August 1, 2017
Summary
Elevated plasma levels of certain metals, including manganese, copper, zinc, arsenic, selenium, and cadmium, are linked to an increased risk of developing type 2 diabetes in the Han Chinese population.
Area of Science:
- Environmental Health
- Metabolomics
- Toxicology
Background:
- Metals are prevalent in consumer products and the environment, with some identified as endocrine disruptors.
- Understanding the link between environmental metal exposure and metabolic diseases like type 2 diabetes is crucial.
Purpose of the Study:
- To investigate the association between plasma concentrations of 20 trace elements and heavy metals and the risk of type 2 diabetes.
- To explore these associations within a Han Chinese population.
Main Methods:
- A case-control study design was employed.
- 122 newly diagnosed type 2 diabetes cases and 429 matched controls were recruited.
- Plasma metal concentrations were quantified using inductively-coupled plasma mass spectrometry.
Main Results:
- Plasma levels of vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were significantly associated with diabetes risk.
- Increased concentrations of vanadium, manganese, copper, zinc, and cesium correlated with higher odds ratios for diabetes.
Conclusions:
- Several metals, including manganese, copper, zinc, arsenic, selenium, and cadmium, are associated with type 2 diabetes morbidity.
- Further research and monitoring of environmental metal exposure are warranted to mitigate diabetes risk.
Related Concept Videos
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K
01:22Diabetes Mellitus: Type 2 and Gestational
5.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
547
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
547