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Updated: Feb 25, 2026

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

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Future Supply Chains Enabled by Continuous Processing-Opportunities Challenges May 20-21 2014 Continuous

Jagjit Singh Srai¹, Clive Badman², Markus Krumme³

¹Department of Engineering, Institute for Manufacturing, University of Cambridge, Cambridge, United Kingdom.

Journal of Pharmaceutical Sciences

|August 1, 2017

Summary

The pharmaceutical industry faces challenges transitioning to continuous processing supply chains. This shift can improve drug availability and affordability by enabling real-time, demand-based production with lower inventory.

Keywords:

bioavailability biopharmaceuticals characterization chemical stability controlled delivery controlled release polymorphism processing tableting

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Area of Science:

Pharmaceutical manufacturing
Supply chain management
Process engineering

Background:

Current pharmaceutical manufacturing relies on large-batch, centralized models, leading to inflexibility and high inventory.
Evolving markets and technology necessitate more adaptable supply chains for diverse, shorter-lifecycle drugs.
Existing models struggle with increasing product complexity and the need for enhanced patient access and affordability.

Purpose of the Study:

To examine the opportunities and challenges of transitioning to continuous processing in pharmaceutical supply chains.
To explore the potential of pull-driven, demand-based supply chains utilizing continuous manufacturing.
To discuss future supply chain models that enhance drug affordability and availability.

Main Methods:

Literature review and conceptual analysis of pharmaceutical supply chain models.
Discussion of continuous processing technologies and their integration into supply chains.
Evaluation of potential benefits and challenges of continuous versus batch manufacturing.

Main Results:

Continuous processing offers a pathway to more flexible, responsive pharmaceutical supply chains.
Adoption of continuous manufacturing can support right-first-time quality with reduced inventory levels.
Hybrid or full continuous solutions can be viable for selected product supply chains.

Conclusions:

Continuous processing is a key enabler for future pharmaceutical supply chains.
The transition to continuous manufacturing can address challenges of product variety and shorter lifecycles.
Continuous supply chains promise improved drug affordability and availability for patients.