Related Experiment Video
Updated: Feb 25, 2026
11:04
Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
Published on: June 23, 2018
7.7K
Protein aggregation, cardiovascular diseases, and exercise training: Where do we stand?
Marisol Gouveia1, Ke Xia2, Wilfredo Colón2
1Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Ageing Research Reviews
|August 1, 2017
Summary
Aging impairs cellular protein quality control, leading to protein aggregates and cardiovascular disease. Exercise training may restore proteostasis (protein homeostasis) and improve heart health.
Area of Science:
- Molecular Biology
- Cardiovascular Science
- Aging Research
Background:
- Cellular proteostasis network maintains protein quality control.
- Reduced proteostasis efficiency with aging contributes to protein misfolding and aggregation.
- Protein aggregate accumulation is linked to cardiovascular diseases like atherosclerosis and heart failure.
Purpose of the Study:
- To review age-related protein aggregation and its impact on cardiovascular pathophysiology.
- To discuss the role of the proteostasis network in cardiovascular disease development.
- To explore how exercise training can restore proteostasis and benefit cardiovascular health.
Main Methods:
- Literature review on proteostasis, aging, and cardiovascular disease.
- Analysis of the interplay between protein aggregation and heart conditions.
- Examination of exercise's effects on proteostasis mechanisms.
Main Results:
- Aging compromises the proteostasis network, promoting protein misfolding.
- Misfolded protein aggregates are implicated in cardiovascular disease progression.
- The proteostasis network can have both beneficial and detrimental effects on cardiovascular health.
Conclusions:
- Declining proteostasis is a key factor in age-related cardiovascular disease.
- Exercise training shows potential to counteract proteostasis decline.
- Lifestyle interventions like exercise may improve cardiovascular outcomes by restoring protein homeostasis.
Related Concept Videos
01:20Exercise and Cardiovascular Response
4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
01:17Exercise and Cardiac Output
2.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
2.3K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
633
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
633
01:26Atherosclerosis III: Management
482
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
482
01:30Coronary Artery Disease I: Introduction
1.3K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
01:26Coronary Artery Disease II: Pathophysiology
805
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
805