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Adrenoceptor function in the bovine pulmonary circulation.

K J Greenlees, R Gamble, P Eyre

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1986
    PubMed
    Summary
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    Alpha- and beta-agonists affect bovine pulmonary circulation differently. Phenylephrine increased pulmonary vascular resistance, while isoproterenol decreased it dose-dependently in pulmonary arteries and veins.

    Area of Science:

    • Veterinary Physiology
    • Cardiovascular Pharmacology

    Background:

    • Understanding pulmonary vascular responses to agonists is crucial for managing bovine respiratory and cardiovascular conditions.
    • Alpha- and beta-adrenergic receptors play significant roles in regulating vascular tone.

    Purpose of the Study:

    • To investigate the distinct effects of alpha- and beta-agonists on the pulmonary vasculature in awake, intact calves.
    • To characterize the dose-dependent responses of pulmonary arterial and venous resistance to these agonists.

    Main Methods:

    • Utilized an awake intact calf model to measure hemodynamic parameters.
    • Administered graded infusions of phenylephrine (alpha-agonist) and isoproterenol (beta-agonist).
    • Monitored pulmonary arterial pressure, wedge pressure, systemic arterial pressure, and cardiac output.

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    Main Results:

    • Phenylephrine significantly increased pulmonary vascular resistance, with a more pronounced effect on the arterial compartment.
    • Isoproterenol induced a dose-dependent reduction in pulmonary vascular resistance in both arteries and veins.
    • Isoproterenol also caused transient decreases in arterial pH and increases in packed cell volume and hemoglobin.

    Conclusions:

    • Alpha- and beta-agonists exert differential effects on bovine pulmonary vascular resistance.
    • Isoproterenol demonstrates potent vasodilatory effects in the pulmonary circulation, impacting both arterial and venous beds.
    • These findings provide insights into the physiological regulation of pulmonary circulation in cattle.