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Updated: Feb 25, 2026

Isolation of Primary Mouse Lung Endothelial Cells

Isolation of Primary Mouse Lung Endothelial Cells

Published on: November 10, 2021

Endothelial Cell Function and Dysfunction in Critically Ill Children.

Richard W Pierce¹, John S Giuliano², Jordan S Pober³

¹Departments of Pediatrics and richard.pierce@yale.edu.

|August 1, 2017

Summary

This summary is machine-generated.

Endothelial cells (ECs) are crucial for vascular health and are implicated in critical illnesses. This review explores how ECs adapt, activate, or dysfunction during critical illness, impacting homeostasis and pathology.

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Last Updated: Feb 25, 2026

Isolation of Primary Mouse Lung Endothelial Cells

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Published on: November 10, 2021

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Published on: April 27, 2016

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

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Published on: May 5, 2023

Area of Science:

Vascular Biology
Critical Care Medicine
Cellular Physiology

Background:

Endothelial cells (ECs) form the inner lining of the vascular system.
ECs regulate vital functions including blood flow, fluidity, and transport.
Their widespread distribution implicates ECs in all critical illnesses.

Purpose of the Study:

To review the adaptive and detrimental changes in endothelial cells during critical illness.
To highlight the role of ECs in maintaining and disrupting homeostasis.
To discuss clinical correlations and studies in critically ill children.

Main Methods:

Review of existing literature on endothelial cell biology in critical illness.
Analysis of EC activation and dysfunction pathways.
Examination of clinical data and pediatric studies.

Main Results:

ECs exhibit segmental differences and specific homeostatic roles.
EC activation can restore homeostasis, while dysfunction contributes to pathology.
Clinical correlations demonstrate the impact of EC changes in critical illness.

Conclusions:

Endothelial cell adaptation and breakdown are central to critical illness.
Understanding EC behavior is key to managing critical conditions.
Research in critically ill children provides specific insights into EC roles.