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Lyophilic matrix method for dissolution and release studies of nanoscale particles
Jenni Pessi1, Sami Svanbäck1, Ilkka Lassila2
1Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5e, 00790, Helsinki, Finland.
Journal of Pharmaceutical and Biomedical Analysis
|August 1, 2017
Summary
A novel lyophilic matrix method (LM method) improves powder dissolution studies by distinguishing undissolved particles from dissolved substances. This technique offers realistic results, particularly for nanoscale particles, overcoming limitations of current dissolution tests.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Dissolution studies are crucial for characterizing drug release and powder behavior.
- Current methods face challenges in accurately assessing dissolution for particulate systems, especially those with nanoscale particles.
- Dispersion of undissolved particles and diffusion barriers can complicate dissolution testing.
Purpose of the Study:
- To introduce a novel lyophilic matrix method (LM method) for enhanced dissolution studies.
- To enable accurate discrimination between dissolved and undissolved species in particulate systems.
- To overcome limitations of existing dissolution tests, particularly for nanopowders.
Main Methods:
- Embedding test substances within a thin, lyophilic core-shell matrix.
- Utilizing the matrix to facilitate rapid contact with dissolution media.
- Minimizing dispersion of non-dissolved particles while avoiding significant diffusion barriers.
Main Results:
- The LM method successfully discriminates between dissolved and undissolved particles.
- Realistic dissolution and release profiles were obtained for particulate systems.
- The method demonstrated particular efficacy for systems containing nanoscale particles.
Conclusions:
- The lyophilic matrix method provides a more accurate approach to dissolution testing.
- It minimizes method-induced artifacts, yielding reliable data for nanopowders.
- This technique enhances the characterization of dissolution behavior for challenging particulate systems.
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