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Approaching to DM2 through sodium-glucose cotransporter-2: does it make sense?
1Unidad de Hipertensión Arterial, Servicio de Nefrología, Hospital Universitario 12 de Octubre, Madrid, España.
Medicina Clinica
|August 2, 2017
Summary
The kidney reabsorbs glucose, primarily via the SGLT2 transporter in the proximal tubule. Blocking this transporter may help manage hyperglycemia in type 2 diabetes.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Diseases
Background:
- The kidney plays a crucial role in glucose homeostasis through gluconeogenesis, consumption, and reabsorption.
- Glucose reabsorption in the proximal tubule prevents urinary glucose loss and calorie depletion.
- The SGLT2 transporter is the primary mediator of renal glucose reabsorption.
Purpose of the Study:
- To examine the role of renal glucose reabsorption in maintaining hyperglycemia.
- To investigate the potential of SGLT2 inhibition for managing hyperglycemia in type 2 diabetes.
Main Methods:
- Analysis of renal glucose transport mechanisms, including transporter locations (SGLT2, GLUT2, SGLT1, GLUT1).
- Review of experimental and clinical studies on SGLT2 blockade.
Main Results:
- The proximal tubule, particularly the S1 segment with SGLT2, reabsorbs about 90% of filtered glucose.
- In hyperglycemic states, the kidney continues glucose reabsorption, contributing to elevated blood glucose levels.
- SGLT2 is the main transporter responsible for this reabsorption.
Conclusions:
- Pharmacological blockade of the SGLT2 transporter shows promise for improving hyperglycemia management in type 2 diabetes patients.
- Targeting renal glucose reabsorption offers a potential therapeutic strategy for diabetes treatment.
Keywords:
Diabetes tipo 2Glucose homeostasisHomeostasis de la glucosaReabsorción renal de glucosaRenal glucose reabsorptionType 2 diabetesMore Related Videos
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