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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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TRPs and Ca2+ in cell death and survival

Ingrid Fliniaux1, Emmanuelle Germain1, Valerio Farfariello1

  • 1Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq 59656, France.

Cell Calcium
|August 2, 2017
PubMed

Insights

Transient Receptor Potential (TRP) channels control cell survival by regulating cation influx. This review explores how TRP channels influence cell fate and various diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Transient Receptor Potential (TRP) channels are crucial ion channels involved in cellular responses to environmental stimuli.
  • These channels mediate the influx of cations, influencing cellular processes and cell death rates.
  • TRP channel activity, particularly calcium (Ca 2+ ) influx, generates specific intracellular signals that impact cell survival or apoptosis.

Purpose of the Study:

  • To review the current understanding of how TRP channels regulate cell fate.
  • To explore the role of TRP channels in various pathologies.
  • To highlight the significance of TRP channels in cellular signaling pathways.

Main Methods:

  • Literature review of existing studies on TRP channels and cell fate.
  • Analysis of research on TRP channel function in different cellular contexts.
  • Synthesis of data linking TRP channel activity to disease mechanisms.

Main Results:

  • TRP channels significantly influence cell death and survival rates through modulation of cation influx.
  • Distinct intracellular Ca 2+ signals generated by TRP channels regulate downstream apoptotic or survival pathways.
  • Dysregulation of TRP channel function is implicated in cardiovascular, neurological, metabolic, and neoplastic disorders.

Conclusions:

  • TRP channels are key regulators of cell fate, impacting cellular survival and death.
  • Understanding TRP channel mechanisms offers insights into the pathogenesis of diverse diseases.
  • Targeting TRP channels may present therapeutic strategies for various pathological conditions.
Keywords:
ApoptosisAutophagyCell deathSurvivalTRP channels

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