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Published on: May 18, 2018
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Blood lactate concentration in diabetic dogs
Poliana Claus1, André M Gimenes1, Jacqueline R Castro1
1Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
Summary
Diabetic dogs, including those with diabetic ketoacidosis (DKA), do not show significantly different blood lactate levels compared to healthy dogs. Further research on lactate isomers is needed to understand their role in canine diabetes.
Area of Science:
- Veterinary Medicine
- Canine Endocrinology
- Clinical Pathology
Background:
- Elevated blood lactate levels are observed in human diabetic patients.
- Lactate monitoring is crucial in critical care, but data for diabetic dogs is limited.
- Understanding lactate's role in canine diabetes pathophysiology is essential.
Purpose of the Study:
- To determine and compare blood lactate concentrations in diabetic dogs versus non-diabetic controls.
- To investigate lactate levels across different stages of diabetes in dogs, including diabetic ketoacidosis (DKA).
Main Methods:
- Prospective, cross-sectional clinical study.
- Inclusion of 75 diabetic dogs (newly diagnosed, insulin-treated, DKA) and 25 non-diabetic controls.
- Measurement of blood lactate concentrations (mmol/L) in all groups.
Main Results:
- No statistically significant difference in lactate levels was found among the control, newly diagnosed, insulin-treated, and DKA groups (P = 0.20).
- Median lactate levels ranged from 1.69 to 2.40 mmol/L across the different canine groups.
- Specific median and interquartile ranges were provided for each group.
Conclusions:
- Blood lactate concentrations do not differ significantly between diabetic dogs (including DKA) and non-diabetic controls.
- Further longitudinal studies are required to explore the role of L- and D-lactate isomers in canine diabetes.
- Additional research is needed to clarify lactate's role in the acid-base status of diabetic dogs.
