Localisation of heparin in mast cells

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In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

M F Scully, V Ellis, V V Kakkar

    Lancet (London, England)
    |September 27, 1986
    PubMed

    Heparin is localised in mast cells as an activator of the contact system. The potent anticoagulant properties of heparin confine this activation to the top half of the intrinsic pathway, and coagulation is prevented. Certain mast cells contain chondroitin sulphate E, which can also activate the contact system but is a weak inhibitor of coagulation. The localisation of these mast cells to the intestine suggests that coagulation is required for effective inflammatory response in the intestinal wall.

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