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Published on: September 6, 2017
Nomenclature and Serology of HLA Class I and Class II Alleles
James McCluskey1, Carmel Kanaan2, Mary Diviney2
1University of Melbourne and Australian Red Cross Blood Service, Melbourne, Australia.
Abstract:
This overview presents nomenclature and serology information on human leucocyte antigens, or HLA molecules, which are encoded by a cluster of genes linked on the short arm of chromosome 6. This region is known as the major histocompatibility complex and codes for class I and class II molecules, which are distinguished from each other based upon their structure, tissue distribution, and source of peptide antigen, as well as upon their interactions with T cell subsets. © 2017 by John Wiley & Sons, Inc.
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