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Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.9K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

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Crowd sourcing difficult problems in protein science.

Nathan S Alexander1, Krzysztof Palczewski1,2

  • 1Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106.

Protein Science : a Publication of the Protein Society
|August 2, 2017
PubMed
Summary
This summary is machine-generated.

Research groups can overcome computing resource limitations by using passive volunteer computing and engaging volunteer computing. These methods leverage idle computing power and human intuition to accelerate scientific discovery.

Keywords:
crowd sourcingdistributed computinginteraction networksprotein structure predictionprotein-ligand dockingvolunteer computing

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Area of Science:

  • Computer Science
  • Computational Science
  • Distributed Computing

Background:

  • Dedicated computing resources are costly to develop, maintain, and administer.
  • Research often faces limitations due to insufficient computing power, especially during peak demand.
  • Idle computing devices represent a significant underutilized resource.

Purpose of the Study:

  • To explore methods for alleviating bottlenecks in research computing resources.
  • To introduce passive and engaging volunteer computing as solutions.
  • To showcase the potential of volunteer computing in scientific research.

Main Methods:

  • Passive volunteer computing: utilizing idle computing power from personal devices.
  • Engaging volunteer computing: incorporating human intuition for complex problem-solving.
  • Highlighting four case studies of successful volunteer computing projects.

Main Results:

  • Passive volunteer computing effectively harnesses underutilized computational power.
  • Engaging volunteer computing can yield high-quality solutions for problems lacking efficient algorithms.
  • Volunteer computing offers a viable alternative to expensive dedicated resources.

Conclusions:

  • Volunteer computing, both passive and engaging, presents a cost-effective strategy to augment research computing capabilities.
  • Leveraging distributed and human-powered computation can accelerate scientific progress.
  • Further development of engaging volunteer computing projects is encouraged.