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Chronic complications of venous thromboembolism

M-P Winter1,2, G H Schernthaner3, I M Lang1,2

  • 1Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.

Journal of Thrombosis and Haemostasis : JTH
|August 2, 2017
PubMed

Insights

Venous thromboembolism (VTE) causes significant mortality and recurrence. This review details chronic VTE complications like postthrombotic syndrome and pulmonary hypertension, summarizing their epidemiology, diagnosis, and treatment.

Area of Science:

  • Cardiovascular Medicine
  • Hematology

Background:

  • Venous thromboembolism (VTE) affects ~700 per 100,000 individuals annually.
  • VTE is linked to high recurrence rates, chronic complications, and mortality up to 40% at 10 years.
  • Current anticoagulant therapies have improved acute VTE treatment but not chronic complication management.

Purpose of the Study:

  • To provide a comprehensive review of VTE-related chronic complications.
  • To summarize the epidemiology, diagnosis, and treatment strategies for postthrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (CTEPH).

Main Methods:

  • Literature review of VTE chronic complications.
  • Synthesis of epidemiological data on PTS and CTEPH.
  • Analysis of current diagnostic and therapeutic approaches.

Main Results:

  • Impaired thrombus resolution underlies VTE complications, including PTS and CTEPH.
  • PTS affects up to 50% of patients post-deep vein thrombosis.
  • CTEPH diagnosis is less defined, affecting a smaller patient subset post-pulmonary embolism.

Conclusions:

  • Chronic complications significantly impact VTE patient morbidity and healthcare costs.
  • Further research is needed for effective prevention and treatment of VTE-related chronic conditions.
  • A unified approach to managing VTE complications is essential.

Keywords:
CTEPHanticoagulantspostthrombotic syndromethrombosisvenous thromboembolism

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