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Updated: Feb 25, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[The Problem of Minimally Changed Coronary Arteries at Elective Coronary Angiography]
A N Sumin1, E V Korok1, M A Sinkov1
1Research Institute for Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Insights
A significant portion of patients undergoing elective coronary angiography have clean coronary arteries. These patients are typically younger females with lower risk factors for ischemic heart disease.
Area of Science:
- Cardiology
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Elective coronary angiography (ECAG) is a key diagnostic tool for assessing CAD.
- Understanding the characteristics of patients with normal coronary arteries is crucial for risk stratification and resource allocation.
Purpose of the Study:
- To determine the incidence of normal coronary arteries in patients undergoing ECAG.
- To identify patient demographics and clinical factors associated with "clean" coronary arteries.
Main Methods:
- Retrospective review of 711 patient records undergoing ECAG.
- Classification of patients into four groups based on the severity of coronary artery stenosis (CAS).
- Statistical analysis to compare patient characteristics across groups.
Main Results:
- 32.9% of patients had no significant coronary artery stenosis (CAS).
- Patients with normal coronary arteries were more likely to be younger females.
- This group exhibited lower pretest probability of ischemic heart disease (IHD), fewer diabetics, and less history of myocardial infarction (MI).
- Atypical angina and cardialgia were more prevalent in the "clean" artery group.
- Patients with normal arteries were more frequently scheduled for ECAG before valvular heart surgery or due to arrhythmias.
Conclusions:
- A substantial percentage of patients undergoing ECAG present with normal coronary arteries.
- Demographic and clinical profiles of these patients differ significantly from those with significant CAD.
- Identifying these patients aids in refining diagnostic strategies and understanding the broader spectrum of indications for ECAG.
Aim:
to study rates and possible causes of detecting "clean" coronary arteries at elective coronary angiography.
Material And Methods:
Medical records of 711 patients who had undergone elective coronary angiography (ECAG) between 01/04 and 31/05 2014 were retrospectively reviewed. Four groups were distinguished: group 1 - patients with normal coronary arteries (n=234), group 2 - patients with coronary artery stenoses (CAS) <60% (n=94), group 3 - patients with 60-69% CAS (n=22), group 4 - patients with CAS more or equal 70% (n=361).
Results:
Most patients were men (p<0.001), except group 1, where women prevailed (p<0.05). Patients in groups 3 and 4 were older than in groups 1 and 2 (p=0.019). Symptoms of angina were less likely to be found in group 1 (p<0.001). History of myocardial infarction (MI) prevailed in group 4 (p<0.001). Arrhythmias were detected more frequently in group 1 (p<0.001); there were less diabetics in this group (p=0.010). Group 1 contained more patients examined before cardiac valve surgery (p<0.001). Typical angina was more often found in group 4, whereas atypical angina - in group 1 (p<0.001). Cardialgia prevailed in groups 1 and 2 (p<0.001). Holter ECG monitoring was used more frequently in group 1 (p<0.001). Symptoms of latent coronary insufficiency were mainly reported in group 1 (p=0.006). The pretest probability of ischemic heart disease (IHD) was higher in groups 2 and 4 compared to group 1 (p<0.001).
Conclusion:
Among patients who had undergone ECAG 32.9% had no CAS. Younger females without history of MI and diabetes as well as patients with atypical angina or cardialgia prevailed in this group. This group of patients had the lowest pretest probability of IHD (58%). Patients without CAS were more often scheduled for EGAG before valvular heart surgery and because of cardiac arrhythmias.
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