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Related Experiment Video

Updated: Feb 25, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
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Modulation of Lung Function by Increased Nitric Oxide Production.

Md Nazrul Islam1, Ram Lochan Yadav2, Prakash Kumar Yadav2

  • 1Professor, Department of Physiology, Chitwan Medical College, Bharatpur, Chitwan, Nepal.

Journal of Clinical and Diagnostic Research : JCDR
|August 3, 2017
PubMed
Summary
This summary is machine-generated.

Garlic supplementation improved lung function in smokers by increasing Nitric Oxide Synthase (NOS) activity. This study shows garlic may help reverse smoking-related pulmonary damage.

Keywords:
GarlicNitric oxidePulmonary functionSmoking

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Area of Science:

  • Pulmonary Medicine
  • Nutritional Science
  • Cardiovascular Research

Background:

  • Cigarette smoking impairs Nitric Oxide (NO) production by reducing Nitric Oxide Synthase (NOS) activity, contributing to pulmonary diseases.
  • NO/oxygen blends aid pulmonary vasodilation in critical care.
  • Garlic demonstrates significant NOS activation potential.

Purpose of the Study:

  • To evaluate the impact of garlic supplementation on the pulmonary function of chronic smokers.

Main Methods:

  • Pulmonary function tests (FVC, FEV1, FEV1/FVC, PEFR) were conducted on non-smokers and smokers.
  • Smokers received 4g raw garlic daily for three months.
  • Endogenous NO production and NOS activity were assessed before and after supplementation.

Main Results:

  • Smokers exhibited significantly reduced pulmonary function and NOS activity compared to non-smokers.
  • Garlic supplementation in smokers led to significant improvements in pulmonary function tests.
  • Improved pulmonary function correlated with increased NOS activity post-garlic supplementation.

Conclusions:

  • Dietary garlic supplementation can significantly enhance pulmonary function in smokers.
  • Increased NOS activity is a likely mechanism behind garlic's beneficial effects on lung health.
  • Garlic represents a potential nutritional strategy to mitigate smoking-induced pulmonary impairment.