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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

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Peripheral Smear Review and Bone Marrow Biopsy Correlation.

Adrian R Bersabe¹, James K Aden², Nathan M Shumway³

¹Fellow, Department of Internal Medicine: Hematology/Oncology, San Antonio Military Medical Centre, Fort Sam Houston, Texas, USA.

Journal of Clinical and Diagnostic Research : JCDR

|August 3, 2017

Summary

Peripheral Blood Smear (PBS) interpretation is a crucial skill for Haematology/Oncology Clinicians (HOCs). Reviewing PBS aids in guiding further diagnostic workups and decisions on Bone Marrow Biopsies (BMBs) for benign hematologic disorders.

Keywords:

Blood platelets Erythrocyte Leukocyte Peripheral blood

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Area of Science:

Hematology
Clinical Pathology

Background:

Peripheral Blood Smear (PBS) interpretation is a valuable skill for Haematology/Oncology Clinicians (HOCs).
Understanding PBS utilization is key for diagnosing benign hematologic conditions.

Purpose of the Study:

To examine how HOCs utilize PBS in diagnosing benign hematologic disorders.
To assess the role of PBS in guiding further investigations and Bone Marrow Biopsy (BMB) decisions.

Main Methods:

Retrospective review of 451 outpatient referrals for benign hematologic diagnoses.
Analysis of PBS ordering, review, and subsequent diagnostic testing.
Comparison of BMB rates with and without prior PBS review.

Main Results:

PBS was ordered in 47.4% of complete blood counts (CBCs).
PBS review led to further testing in 41.4% of documented cases.
BMBs were performed more frequently when PBS was reviewed (11.5% vs. 4.3%), yielding higher diagnostic rates (27.8% vs. 43.8%).

Conclusions:

PBS interpretation is an essential skill for HOCs.
Training programs should emphasize PBS proficiency to enhance diagnostic accuracy.
Effective PBS use can optimize the diagnostic evaluation of hematologic disorders.