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Validation of the PLASMIC score at a University Medical Center
Ryan Jajosky1, Mark Floyd1, Thomas Thompson1
1Augusta University Medical Center, United States.
Summary
The PLASMIC score effectively predicts low ADAMTS13 activity in suspected thrombotic thrombocytopenic purpura (TTP) cases. This validation confirms its utility in clinical settings for rapid TTP assessment.
Area of Science:
- Hematology
- Clinical Diagnostics
Background:
- Thrombotic thrombocytopenic purpura (TTP) diagnosis can be aided by predicting ADAMTS13 activity.
- The PLASMIC score offers a convenient method for predicting low ADAMTS13 activity while awaiting laboratory results.
Purpose of the Study:
- To validate the diagnostic utility of the PLASMIC score at a University Medical Center.
- To assess the PLASMIC score's accuracy in predicting ADAMTS13 activity ≤10% in patients with suspected TTP.
Main Methods:
- Retrospective review of apheresis records from 2008-2017.
- Inclusion of patients who underwent plasma exchange (PLEX) for suspected TTP.
- Recording of ADAMTS13 activity and PLASMIC scoring criteria for analysis.
Main Results:
- Out of 41 identified patients, 20 met inclusion criteria; 7 had ADAMTS13 activity ≤10%.
- Intermediate and high PLASMIC scores demonstrated 100% sensitivity and 100% negative predictive value.
- Specificity was 46.2% and positive predictive value was 50% for these scores.
Conclusions:
- The study findings align with the original PLASMIC score validation.
- The results support the PLASMIC score's efficacy and confirm its applicability in institutional practice.
- The PLASMIC score is a valuable tool for the initial assessment of TTP.
