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Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors
Published on: September 24, 2014
[Pediatric brain tumors]
W Reith1, S Bodea, R Mühl-Benninghaus2
1Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Deutschland. Wolfgang.Reith@uks.eu.
Insights
Pediatric brain tumors, such as medulloblastomas and low-grade astrocytomas, differ from adult brain tumors in histology and location. This review outlines key imaging criteria for common childhood brain tumors.
Area of Science:
- Pediatric Oncology
- Neuroradiology
- Neuro-oncology
Background:
- Brain tumors exhibit distinct histological and localization patterns in pediatric versus adult populations.
- Malignant gliomas and meningiomas are common in adults, whereas medulloblastomas and low-grade astrocytomas are prevalent in children.
- Pediatric brain tumors predominantly occur in the infratentorial region (50-70%), contrasting with the approximately 30% infratentorial incidence in adults.
Purpose of the Study:
- To differentiate common pediatric brain tumors from adult types.
- To highlight the characteristic locations and imaging features of pediatric brain tumors.
- To provide essential imaging criteria for diagnosing common pediatric brain tumors.
Main Methods:
- Review of diagnostic imaging modalities including sonography, cranial computed tomography (CCT), and magnetic resonance imaging (MRI).
- Analysis of space-occupying characteristics, density, and intensity variations compared to normal brain parenchyma.
- Description of extrusive growth, parenchymal infiltration, and intrinsic origins of tumors.
Main Results:
- Identification of key differences in tumor types (e.g., medulloblastoma, astrocytoma) and their locations between pediatric and adult populations.
- Recognition of brain tumors via imaging based on mass effect and signal/density alterations.
- Outline of the most common pediatric brain tumors: astrocytoma, medulloblastoma, brainstem glioma, craniopharyngioma, neurofibromatosis, and ganglioglioma.
Conclusions:
- Understanding the unique characteristics of pediatric brain tumors is crucial for accurate diagnosis.
- Imaging plays a vital role in identifying and characterizing brain tumors in children.
- This article provides a foundational overview of common pediatric brain tumors and their imaging criteria.
Abstract:
Brain tumors differ between children and adults both in histology and localization. Malignant gliomas and meningiomas predominate in adults while medulloblastomas and low-grade astrocytomas are the most frequent brain tumors in children. More than one half (50-70%) of pediatric brain tumors have an infratentorial location but only approximately 30% in adults. Brain tumors can be recognized in sonography, cranial computed tomography (CCT) and magnetic resonance imaging (MRI) by their space-consuming character and by their divergent density and intensity in comparison to normal brain parenchyma. They can grow extrusively, even infiltrate the parenchyma or originate from it. Besides clinical symptoms and diagnostics this article describes the most common pediatric brain tumors, i.e. astrocytoma, medulloblastoma, brainstem glioma, craniopharyngioma, neurofibromatosis and ganglioglioma. The most important imaging criteria are outlined.

