Resistance to Propofol Induction in a Patient Taking Modafinil: A Case Report
1From the Department of Anesthesiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.
A & a Case Reports
|August 3, 2017
Summary
Modafinil may reduce the effectiveness of propofol anesthesia, requiring alternative agents like sevoflurane. This finding is crucial for anesthesiologists managing patients on modafinil.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol is a common intravenous anesthetic agent.
- Modafinil is a wakefulness-promoting drug with potential central nervous system effects.
Observation:
- A patient receiving modafinil exhibited resistance to the anesthetic effects of propofol.
- Adequate anesthetic depth was achieved with sevoflurane despite propofol unresponsiveness.
Findings:
- High doses of propofol failed to induce adequate anesthesia in a patient taking modafinil.
- Sevoflurane effectively induced and maintained anesthesia, suggesting modafinil's interaction with propofol's mechanism.
Implications:
- Clinicians should consider potential modafinil-induced propofol resistance when planning anesthesia.
- Further research is needed to elucidate the interaction between modafinil and anesthetic agents.
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