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Hyperbaric oxygen for persistent post-concussive symptoms: long-term follow-up.

Leonard D Skipper^1,2, Susan Churchill³, Steffanie H Wilson⁴

¹Hyperbaric Oxygen Project Office, US Army Medical Materiel Development Activity (USAMMDA), Fort Detrick, Maryland U.S.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc

|August 3, 2017

Summary

This summary is machine-generated.

Long-term follow-up of hyperbaric oxygen (HBO₂) trials for persistent post-concussive symptoms (PCS) showed no improvement in PCS or PTSD. Low participation and retention challenge military research.

Keywords:

attrition mild traumatic brain injury post-concussive syndrome retention

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Area of Science:

Neurology
Military Medicine
Hyperbaric Medicine

Background:

Persistent post-concussive symptoms (PCS) and post-traumatic stress disorder (PTSD) are common in military personnel.
Hyperbaric oxygen (HBO₂) therapy has been investigated as a treatment for PCS.
Long-term outcomes and challenges in military research are crucial.

Purpose of the Study:

To investigate long-term follow-up results of HBO₂ trials for PCS in military personnel.
To assess challenges in recruitment and retention within active-duty military research.
To evaluate the persistence of PCS, PTSD, anxiety, depression, and quality of life over time.

Main Methods:

Observational cohort study with long-term follow-up.
Electronic survey assessing PCS, PTSD, anxiety, depression, and quality of life.
Analysis of data from two completed US military trials (DARPA/VCU and HOPPS).

Main Results:

Low survey completion rate (30%) due to inability to contact, loss to follow-up, or refusal.
Participants reported continued PTSD, depression, anxiety, and reduced quality of life.
Descriptive analyses indicated no improvement in PCS or PTSD symptoms over time; some groups showed worsening scores.

Conclusions:

Limited participation and potential response bias restrict definitive conclusions.
PCS and PTSD symptoms may not improve long-term with HBO₂ therapy in this cohort.
Future studies require prospective longitudinal follow-up and enhanced participant engagement to minimize attrition.