Synthesis of Five and Six-Membered Heterocycles Using Activated Nitriles for Industrial Applications
Refat El-Sayed1,2, Meshal H K Almalki3
1Chemistry Department, College of Applied Sciences, Umm Al-Qura University.
Abstract:
The aim of this study is a synthesis of new bioactive heterocyclic compounds incorporated fatty chain for use in different industrial applications. Cyanoacetamide derivative (2) was successfully transferred into five and six membered heterocyclic derivatives by the reaction with various chemical reagents. Addition number of moles of propylene oxide to these compounds gave nonionic surface-active agents having a good solubility, biodegradability and hence lowers the toxicity to human beings and becomes environmentally friendly. The antimicrobial and surface activities were investigated that showed the most of them have pronounced activity, which makes them suitable for diverse applications like the manufacturing of drugs, pesticides, emulsifiers, cosmetics, etc.
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