Paraneoplastic Sarcoidosis in Multiple Myeloma
Kana Kusaba1, Kensuke Kojima1, Shinji Naito2
1Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
Internal Medicine (Tokyo, Japan)
|August 4, 2017
Summary
This study reports a rare case of paraneoplastic sarcoidosis co-occurring with multiple myeloma. It highlights the need to rule out underlying cancers when diagnosing skeletal sarcoidosis with unusual bone lesions.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Sarcoidosis commonly affects lungs, lymph nodes, and eyes, but rarely the musculoskeletal system.
- Paraneoplastic syndromes can manifest with sarcoidosis, complicating diagnosis.
- Multiple myeloma is a plasma cell malignancy, rarely associated with sarcoidosis.
Observation:
- A patient presented with ocular sarcoidosis and increased 18F-fluorodeoxyglucose uptake in mediastinal lymph nodes and vertebral column.
- Histological examination confirmed sarcoidosis in lymph nodes and multiple myeloma in a vertebral tumor.
Findings:
- The case demonstrates the rare simultaneous occurrence of sarcoidosis and multiple myeloma.
- Ocular sarcoidosis was a presenting feature in this paraneoplastic syndrome.
Implications:
- This case underscores the importance of investigating underlying malignancies before diagnosing skeletal sarcoidosis, especially with atypical bone involvement.
- Early detection of malignancy is crucial for effective treatment of paraneoplastic sarcoidosis.
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