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USE OF AMOXICILLIN AND CLAVULANIC ACID (AUGMENTIN) IN THE TREATMENT OF SKIN AND SOFT TISSUE INFECTIONS IN CHILDREN

P K Kar1

  • 1Classified Specialist (Dermatology & Venerology), 151 Base Hospital, C/O 99 APO.

Medical Journal, Armed Forces India
|August 4, 2017
PubMed

Insights

Amoxicillin plus clavulanic acid effectively treated skin infections in children, showing higher cure rates than amoxicillin, erythromycin, or co-trimoxazole. This antibiotic combination was also well-tolerated, demonstrating its safety and efficacy.

Area of Science:

  • Pediatric Infectious Diseases
  • Dermatology
  • Pharmacology

Background:

  • Skin and soft tissue infections are common in children.
  • Bacterial resistance, particularly from beta-lactamase producing organisms like Staphylococcus aureus, complicates treatment.
  • Amoxicillin plus clavulanic acid offers a potential solution against resistant bacteria.

Purpose of the Study:

  • To compare the efficacy and safety of amoxicillin plus clavulanic acid against amoxicillin, erythromycin, and co-trimoxazole.
  • To evaluate treatment outcomes in children with varying severity of skin and soft tissue infections.
  • To assess the clinical cure rates and tolerability of the antibiotic regimens.

Main Methods:

  • An open-label, randomized trial involving 200 children with skin and soft tissue infections.
  • Infections included impetigo and pyodermas (mild, moderate, severe).
  • Bacteriological analysis identified Staphylococcus aureus and S. pyogenes as common pathogens.

Main Results:

  • Amoxicillin plus clavulanic acid achieved higher clinical cure rates: 84% in mild-to-moderate and 96% in severe pyoderma by week 1.
  • Compared to amoxicillin, erythromycin, and co-trimoxazole, the combination showed superior efficacy.
  • The combination of amoxicillin and clavulanic acid was well-tolerated by pediatric patients.

Conclusions:

  • Amoxicillin plus clavulanic acid is a highly effective treatment for pediatric skin and soft tissue infections, including those caused by resistant bacteria.
  • The combination demonstrates superior clinical outcomes compared to other tested antibiotics.
  • Its favorable safety profile makes it a valuable therapeutic option for children.

Keywords:
AmoxicillinClavulanic acidDrug therapyPyodermacombination

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