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Protein-Based Drug-Delivery Materials.

Dave Jao1,2, Ye Xue3,4, Jethro Medina5

  • 1Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028, USA. jaod07@students.rowan.edu.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Protein-based polymers offer biocompatible, sustainable solutions for controlled drug delivery, overcoming biological barriers for targeted therapies. This review explores their properties and applications in various medical treatments.

Keywords:
collagencontrolled releasedrug deliveryelastinkeratinprotein biopolymersilk

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Chronic diseases require long-term, controlled drug release, posing challenges for therapeutic compound transport across biological barriers.
  • Nanoscale protein-based polymers are emerging as promising carriers for drug and vaccine delivery due to their biocompatibility and biodegradability.

Purpose of the Study:

  • To review protein-based polymers for sustained and controlled drug release.
  • To compare protein-based polymers with synthetic alternatives.
  • To highlight their properties, functionality, and applications in targeted drug delivery.

Main Methods:

  • Review of literature on protein-based polymer sources, properties, and functionalities.
  • Comparison of protein-based polymers with synthetic polymers.
  • Elucidation of drug delivery efficiency based on material characteristics (e.g., molecular weight, particle size, shape, morphology, porosity).

Main Results:

  • Protein-based polymers offer advantages over synthetic polymers, including biocompatibility, biodegradability, sustainability, and cost-effectiveness.
  • Material characteristics significantly influence drug absorption and delivery efficiency.
  • Protein composites can be functionalized for targeted drug delivery.

Conclusions:

  • Protein-based polymers are versatile materials for advanced drug delivery systems.
  • Their tunable properties enable enhanced therapeutic outcomes across diverse biomedical applications.
  • Further research into protein-based materials promises innovative treatments for various diseases.