Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Common Ion Effect03:24

Common Ion Effect

47.4K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
47.4K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

10.4K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
10.4K
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

2.4K
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
2.4K
Ion Exchange01:17

Ion Exchange

1.4K
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
1.4K
Ionic Strength: Effects on Chemical Equilibria01:19

Ionic Strength: Effects on Chemical Equilibria

2.9K
The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
In this solution, the primary...
2.9K
Membrane Domains01:18

Membrane Domains

7.9K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coarse-Grained Simulations of Thermosensitive Polymer Nanocomposites.

Macromolecules·2026
Same author

Probing the Structural Dynamics of the Unbound MAX Protein: Insights from Well-Tempered Metadynamics.

Journal of chemical information and modeling·2025
Same author

High-Contrast Colorless-to-Colored Thermochromic Materials.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Rare-Earth Silicates as High-Temperature Surfactants for the Controlled Synthesis of ε-Fe<sub>2</sub>O<sub>3</sub> Nanoparticles.

Journal of the American Chemical Society·2025
Same author

Excision of organic macrocycles from covalent organic frameworks.

Science (New York, N.Y.)·2025
Same author

Molecular simulation of hybrid polymer nanocomposites with organic nanodimers and inorganic nanorods: From structure and dynamics to viscosity.

The Journal of chemical physics·2025

Related Experiment Video

Updated: Feb 25, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.7K

Specific Ion Effects in Cholesterol Monolayers.

Teresa Del Castillo-Santaella1, Julia Maldonado-Valderrama2, Jordi Faraudo3

  • 1Departamento de Física Aplicada, Universidad de Granada, Campus de Fuentenueva sn, Granada 18071, Spain. tdelcastillo@ugr.es.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary
This summary is machine-generated.

Specific ion effects on cholesterol monolayers were investigated using surface force measurements and molecular dynamics (MD) simulations. Ion type and counterion significantly influence cholesterol interactions at interfaces.

Keywords:
Langmuir monolayerscholesterolionic specificitymolecular dynamics simulationssurface forces

More Related Videos

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
05:27

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Published on: July 20, 2022

2.3K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.7K

Related Experiment Videos

Last Updated: Feb 25, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.7K
Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
05:27

Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools

Published on: July 20, 2022

2.3K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.7K

Area of Science:

  • Surface science
  • Physical chemistry
  • Biophysics

Background:

  • Ion-interface interactions are crucial in surface science.
  • Specific ion effects are known but not fully understood at the molecular level.
  • Cholesterol monolayers are important biological interfaces.

Purpose of the Study:

  • To investigate the impact of different salts on cholesterol monolayers.
  • To elucidate the molecular mechanisms behind specific ion effects.
  • To explore the role of counterions in ion-surface interactions.

Main Methods:

  • Experimental measurements using a Langmuir Film Balance to obtain surface area vs. lateral pressure isotherms.
  • Theoretical analysis via all-atomic molecular dynamics (MD) simulations.
  • Comparison of experimental and simulation data for various salts (NaI, NaCl, CaCl₂, MgCl₂).

Main Results:

  • Surface isotherms showed quantitative and qualitative changes based on ion type.
  • MD simulations confirmed specific ionic effects and provided molecular-level insights into ion-cholesterol interactions.
  • Crucially, ion-surface interaction was found to be strongly dependent on the counterion.

Conclusions:

  • The nature of ions significantly alters the properties of cholesterol monolayers.
  • MD simulations offer detailed molecular understanding of ion-specific interactions.
  • Counterion effects on ion-surface interactions are critical and often overlooked in theoretical models.